EXOSC10

EXOSC10
Cấu trúc được biết đến PDB Tìm trên Human UniProt: PDBe RCSB Danh sách mã id PDB 2CPR, 3SAF, 3SAG, 3SAH
Mã định danh
Danh pháp	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4, exosome component 10
ID ngoài	OMIM: 605960 HomoloGene: 31105 GeneCards: EXOSC10
Mẫu hình biểu hiện RNA Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen Chức năng phân tử • nucleotide binding • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • catalytic activity • 3'-5' exonuclease activity • nucleic acid binding • nuclease activity • exonuclease activity • hydrolase activity • RNA binding • 3'-5'-exoribonuclease activity • telomerase RNA binding • single-stranded RNA binding Thành phần tế bào • tế bào chất • exosome (RNase complex) • membrane • nuclear exosome (RNase complex) • nội bào • Hạch nhân • nhân tế bào • Chất nhân • cytosol Quá trình sinh học • GO:0033168, GO:0036404, GO:1902360 RNA processing • nuclear polyadenylation-dependent rRNA catabolic process • nucleic acid phosphodiester bond hydrolysis • CUT catabolic process • nuclear-transcribed mRNA catabolic process • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • cell metabolism • maturation of 5.8S rRNA • histone mRNA catabolic process • dosage compensation by inactivation of X chromosome • nucleobase-containing compound metabolic process • rRNA processing • RNA phosphodiester bond hydrolysis, exonucleolytic • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of telomere maintenance via telomerase • regulation of telomerase RNA localization to Cajal body • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear polyadenylation-dependent snoRNA catabolic process • nuclear polyadenylation-dependent snRNA catabolic process • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent CUT catabolic process • nuclear polyadenylation-dependent antisense transcript catabolic process • polyadenylation-dependent snoRNA 3'-end processing Nguồn: Amigo / QuickGO
Gen cùng nguồn
Loài	Người	Chuột
Entrez	5394	n/a
Ensembl	ENSG00000171824	n/a
UniProt	Q01780	n/a
RefSeq (mRNA)	NM_001001998 NM_002685	n/a
RefSeq (protein)	NP_001001998 NP_002676	n/a
Vị trí gen (UCSC)	n/a	n/a
PubMed		n/a
Wikidata
Xem/Sửa Người

Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.

Thành phần exosome 10 (tiếng Anh: Exosome component 10), còn được gọi là EXOSC10, là gen ở người, sản phẩm protein của gen là thành phần cấu thành phức hệ exosome và là một tự kháng nguyên (autoantigen), trở thành một mầm bệnh, dẫn đến sinh bệnh tự miễn, nổi bật nhất là chứng scleromyositis.

Đọc thêm

• Blüthner M, Bautz FA (1992). “Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein”. J. Exp. Med. 176 (4): 973–80. doi:10.1084/jem.176.4.973. PMC 2119404. PMID 1383382.
• Ge Q, Frank MB, O'Brien C, Targoff IN (1992). “Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen”. J. Clin. Invest. 90 (2): 559–70. doi:10.1172/JCI115895. PMC 443135. PMID 1644924.
• Allmang C, Petfalski E, Podtelejnikov A, và đồng nghiệp (1999). “The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases”. Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
• Brouwer R, Allmang C, Raijmakers R, và đồng nghiệp (2001). “Three novel components of the human exosome”. J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Stover C, Endo Y, Takahashi M, và đồng nghiệp (2001). “The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3”. Genes Immun. 2 (3): 119–27. doi:10.1038/sj.gene.6363745. PMID 11426320.
• Chen CY, Gherzi R, Ong SE, và đồng nghiệp (2002). “AU binding proteins recruit the exosome to degrade ARE-containing mRNAs”. Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). “Protein-protein interactions of hCsl4p with other human exosome subunits”. J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ, và đồng nghiệp (2002). “Autoantibodies directed to novel components of the PM/Scl complex, the human exosome”. Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). “Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring”. J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Scherl A, Couté Y, Déon C, và đồng nghiệp (2003). “Functional proteomic analysis of human nucleolus”. Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, và đồng nghiệp (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). “The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus”. J. Biol. Chem. 278 (33): 30698–704. doi:10.1074/jbc.M302488200. PMID 12788944.
• Lejeune F, Li X, Maquat LE (2003). “Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities”. Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
• Ota T, Suzuki Y, Nishikawa T, và đồng nghiệp (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, và đồng nghiệp (2004). “A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway”. Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Raijmakers R, Renz M, Wiemann C, và đồng nghiệp (2004). “PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome”. Arthritis Rheum. 50 (2): 565–9. doi:10.1002/art.20056. PMID 14872500.
• Lehner B, Sanderson CM (2004). “A protein interaction framework for human mRNA degradation”. Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, và đồng nghiệp (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• van Dijk EL, Schilders G, Pruijn GJ (2007). “Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways”. RNA. 13 (7): 1027–35. doi:10.1261/rna.575107. PMC 1894934. PMID 17545563.